Molecular Dynamics Simulations of Antibiotic Ceftaroline at the Allosteric Site of Penicillin‐Binding Protein 2a (PBP2a)
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چکیده
منابع مشابه
Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics
Ceftaroline, a recently approved β-lactam antibiotic for treatment of infections by methicillin-resistant Staphylococcus aureus (MRSA), is able to inhibit penicillin-binding protein 2a (PBP2a) by triggering an allosteric conformational change that leads to the opening of the active site. The opened active site is now vulnerable to inhibition by a second molecule of ceftaroline, an event that im...
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ژورنال
عنوان ژورنال: Israel Journal of Chemistry
سال: 2020
ISSN: 0021-2148,1869-5868
DOI: 10.1002/ijch.202000012